In order to thoroughly elucidate the functional role and molecular signaling mechanisms of Sema6C in cancer cells, we assayed the impact of gene knock-down in different tumor cell types, such as pancreatic (CapaN-1, BxPC-3), colorectal (HCT116), ovarian (HEY), and breast (MCF7) human carcinoma cells. Here, SEMA6C is linked to carcinoma.