When tumour epithelial and stromal compartments were examined separately, higher PD-L1+ macrophage density associated with longer cancer-specific survival in both tumour intraepithelial and stromal compartments of the tumour centre and the invasive margin in univariable analyses (all Ptrend < 0.005) (Supplementary Fig. S10, Supplementary Table S4). The gene discussed is CD274; the disease is neoplasm.