CD274 and cancer: We found that higher PD-L1+ M1-like macrophage density in both the tumour centre and the invasive margin predicted longer cancer-specific survival in univariable and multivariable models (multivariable Ptrend = 0.0005 and Ptrend = 0.0008, respectively), while the densities of PD-L1− M1-like macrophages, PD-L1+ M2-like macrophages, or PD-L1− M2-like macrophages did not significantly associate with the survival in multivariable models (all Ptrend > 0.005).