1687C>T in the BRCA1 gene and c.3975_3978dupTGCT and c.7806-2A>G in the BRCA2 gene, which have been previously reported to be the five most common pathogenic variants in BRCA1/2 genes in Slovenian HBOC families, representing 67% of pathogenic variants in Slovenian cancer patients42; together, they represent 71% of the pathogenic variation in BRCA genes in our study. This evidence concerns the gene BRCA1 and cancer.