Apart from some known pairwise relationships such as ASXL2 with RUNX1::RUNX1T1 and IDH2 with PHF6, we observed significant associations of gains of chromosome 6 and 19, two numerical chromosomal changes preferentially found in pediatric AML genomes2, with trisomies 8 and 21 in the absence of other significantly co-occurred gene mutations, suggesting novel modes of cooperative leukemogenesis in pediatric AML. This evidence concerns the gene IDH2 and acute myeloid leukemia.