Second, while epigenetic alterations in pediatric AML are diverse, involving a widespread list of infrequently mutated genes, we observed age-related changes in the WIT pathway involving mutually exclusive mutations of WT1, IDH1/2, and TET2 that are believed to mediate a common DNA hypermethylation phenotype and possible responsiveness to epigenetic drugs. This evidence concerns the gene IDH1 and acute myeloid leukemia.