TP53 and acute myeloid leukemia: GSEA of whole transcriptome sequencing (WTS) data from 56 pediatric AML patients (Supplementary Table 10) with (n = 6) or without (n = 50) TP53 alterations revealed that altered TP53 was positively associated with cell division-related pathways, in particular chromosome segregation, while inhibiting myeloid activation and immune responses (Fig. 6a).