CHEK2 and acute myeloid leukemia: In addition, we identified 30 focal gene-level copy number changes (26 losses and four gains), including recurrent PTPN11 and CHEK2 deletions not previously reported in AML in 21 patients as well as KMT2A-partial tandem duplications (PTDs) in three patients (Supplementary Table 3 and Supplementary Figs. 7–9).