IL4 and neoplasm: For NSCLC, the selected features are cytokines: pretreatment interleukin 4 (pre-IL4), pre-IL15 and slope of Interferon gamma-induced protein 10 (slope-IP10); Tumor PET imaging features/Radiomics: pretreatment Metabolic Tumor Volume (pre-MTV), relative difference (RD) of Gray-level size zone matrices (GLSZM)-large zone low gray-level (LZLGE) and RD-GLSZM-zone size variance (RD-GLSZM-ZSV); Dosimetry: Tumor gEUD and Lung gEUD; Genetics (single nucleotide polymorphism [SNP]): Cxcr1- Rs2234671, Ercc2-Rs238406, and Ercc5-Rs1047768; and MicroRNA: miR-191-5p and miR-20a-5p.