In the present study, LMR had no impact on clinical outcomes, although tumors expressing PD-L1 might have an increased number of circulating monocytes, including MDSC, whereas a decreased number of circulating effector-memory lymphocytes, which play a pivotal role in eliminating tumor cells, as LMR is inversely correlated with PD-L1 TC and IC. The gene discussed is CD274; the disease is neoplasm.