In addition, prostate expression of ETV4 results in the late development of mouse prostatic intraepithelial neoplasia in transgenic mice35 whereas occurrence of metastasis was associated with the late increase of ETV4 expression in a mouse model with several genetic alterations (pTen loss, NKX3.1 deletion, and a KRAS activating mutation) 36. This evidence concerns the gene ETV4 and prostate intraepithelial neoplasia.