Monoclonal antibodies D5 (complex of EV-A71 and D5 fragment PDB: 3JAU) and C4 can simultaneously interfere with EV-A71 binding to SCARB2, PSGL-1, and heparin sulfate, which are expected to be highly effective blockers of viral attachment and internalization, promoting the development of monoclonal antibody-based treatment of EV-A71 infection [36]. This evidence concerns the gene SCARB2 and infection.