Fibulin-3 minimally interacts directly with ECM components such as elastin or fibrillin-1 however it strongly regulates TIMP-3, indicating reduction of fibulin-3 may increase aberrant elastic fiber degradation through protease/anti-protease imbalance in a similar manner to Sorsby Fundus Dystrophy [269]. The gene discussed is EFEMP1; the disease is Sorsby fundus dystrophy.