GO analyses revealed the enrichment of several biological processes that mediate host cellular viral and immune response signaling pathways, especially the induction of proteins representing immune pathways such as IFN and NF-κB signaling, upon infection of SARS-CoV-2 B.1, Delta, and Omicron BA.1 variants (Fig. 4, A and B). The gene discussed is NFKB1; the disease is infection.