Mammalianhistidine-rich glycoprotein (HRG) is a glycosylated proteinof ∼70 kDa in size and is present in blood plasma at relativelyhigh concentrations (∼1.5 μM).1 It has numerous binding partners, such as heparin, plasminogen,divalent metal ions, and heme, and is involved in many essential regulatorybiological processes, including blood coagulation, cell migration,proliferation and adhesion, tumor growth inhibition and angiogenesis,as well as immune complex clearance.1−7 HRG has therefore been referred to as the “Swiss Army knifeof mammalian plasma”.8 The gene discussed is HRG; the disease is neoplasm.