We previously showed that culturing liver tumor cells in soft 3Dsubstrates (stiffness ∼0.1 kPa) profoundly slows down cellularproliferation in a Yes-associated protein 1 (YAP)–mammaliantarget of Rapamycin (mTOR)-mediated manner.33 Further, a recent study indicated that the cellular microenvironmentmechanically regulates glycolysis.34 Therefore,we hypothesized that mechanically modulated metabolic rewiring ofliver tumor cells should be linked to the proliferation and dormantstate of cell. Here, YAP1 is linked to neoplasm.