We understand that there are certain limitationsin our study.The liver ECM in healthy tissues and cancer pathology is more complexand is composed of collagen types I, III, IV, and V; fibronectin;elastin; and many other proteins.111,112 The holisticpresentation of ECM is depicted by introducing the term “matrisome”,e.g., combination of molecules constituting ECM, matrix-associatedenzymes and their inhibitors, growth factors, and the receptors forECM.98 The liver ECM is a very complexand heterogeneous entity that is so far difficult to mimic utilizingcurrent 3D cell culture models. This evidence concerns the gene FN1 and cancer.