To determine whether the enhanced phagolysosome fusion detected during CREB inhibition is due to activation of the necroptotic signaling pathway, we pretreated MDMs with CREB inhibitor 666–15 +/- Nec-1 (RIPK1 inhibitor), GSK’872 (RIPK3 inhibitor) or necrosulfonamide (NSA, MLKL inhibitor) for 1h prior to infection with mCherry expressing M. tb H37Rv. Here, PCSK1 is linked to infection.