ARG1 and diffuse cutaneous Leishmaniasis: Interestingly, in the lesions of diffuse cutaneous leishmaniasis (DCL) the levels of Arg1, Cat2, and SpmS mRNAs were upregulated in relation to localized cutaneous leishmaniasis (LCL) or mucocutaneous leishmaniasis (MCL) patients, correlating with higher levels of ornithine and spermidine, but not of arginine [101, 102].