For example, CCR7 enhances human endometrial stromal cell proliferation by activating the PI3K/Akt signaling pathway (Diao et al. 2017), prevents non-small cell lung cancer apoptosis through the NF-κB and ERK signaling pathways (Xu et al. 2012, Zhang et al. 2017), and promotes the migration and invasion of urinary bladder cancer cells via the MEK/ERK1/2 signaling pathway (Xiong et al. 2017). This evidence concerns the gene MAP2K7 and urinary bladder cancer.