The 12-month rate of hypoglycemia-related ED visits or hospitalizations among patients at high risk was 6.7%, vs 0.3% for those at low or intermediate risk (C statistic = 0.83).1 This tool also performed well in 2 external validations among 1 350 938 patients with diabetes (C statistic = 0.79 and 0.81).1 Kaiser Permanente Northern California (KPNC) uses this tool to identify patients at high risk (those with ≥3 hypoglycemia-related ED visits or hospitalizations and insulin users with any history of hypoglycemia-related ED visits or hospitalizations). This evidence concerns the gene INS and Hypoglycemia.