STAT3 and cancer: Interestingly, a recent study has reported that Brusatol can also lead to the inhibition of STAT3 and of that of the upstream kinases responsible for its activation, in Head and Neck Squamous Cell Carcinoma [42], underscoring the complexity of NRF2 and STAT3 interplay in cancer and thus the difficulty to develop new drugs targeting these pathways [43].