While previous research has shown that RIPK3-dependent necroptosis of pancreatic cancer cells leads to the recruitment of immunosuppressive cells such as MDSCs to create an immunosuppressive tumor microenvironment [10], our study highlights a strong association between necroptosis subtypes and the tumor immune microenvironment in BUC. The gene discussed is RIPK3; the disease is familial pancreatic carcinoma.