CD274 and neoplasm: Interestingly, we discovered that as NecroScore increased, the proportion of positive cells (PD-L1 expression ≥ 1%) also increased in both immune cells and tumor cells in the IMvigor210 cohort, especially in the TC2+ (TC ≥ 5%) and IC2+ (IC ≥ 5%) ratios, which were significantly higher in the high NecroScore group compared to the low NecroScore group (Figs. 8D, E, S17C, D).