The highest mutation frequency of BRAF, ATRX, IDH1, CDKN2A, and EGFR was seen in melanoma (SKCM), thyroid carcinoma (THCA), brain lower-grade glioma (LGG), head and neck squamous cell carcinoma (HNSC), and glioblastoma multiforme (GBM), respectively (Figs. S2B, S4C). The gene discussed is IDH1; the disease is melanoma.