To further understand the underlying mechanisms that GALNT2 facilitates GBM development, several key proteins, including CD44, Sox2, Oct4, and ALDH that mediate the promotion of GSCs self-renewal and GBM progression were detected after silencing GALNT2 and found that only CD44 expression was considerably inhibited upon silencing GALNT2 (Figure 4A and data not shown). The gene discussed is POU5F1; the disease is glioblastoma.