LDHA and glioblastoma: To further understand the underlying mechanisms that GALNT2 facilitates GBM development, several key proteins, including CD44, Sox2, Oct4, and ALDH that mediate the promotion of GSCs self-renewal and GBM progression were detected after silencing GALNT2 and found that only CD44 expression was considerably inhibited upon silencing GALNT2 (Figure 4A and data not shown).