MMP13 and cancer: Most importantly, ELISA results showed that serum MMP13 levels could be used for the diagnosis of multiple tumors, including BRCA, HNSC, LUAD, and LUSC, with the area under the curve (AUC) values of 0.8494, 0.9259, 0.7144, and 0.8575, respectively.<h4>Conclusions</h4>MMP13 is often overexpressed across cancers and predicts poor prognosis, with the potential as a therapeutic target.