In individuals with hypertension who also have diabetes, the first-line antihypertensive drugs are angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs).[7,10] Renin angiotensin aldosterone blockade plays an important role in hypertension control and in the prevention of the progression of DKD. This evidence concerns the gene REN and hypertensive disorder.