But Wang N et al[22] study had shown that rhTPO could not promote the proliferation of Kasumi-1, Skno-1, HEL, HL-60, and THP-1 leukemia cell lines; On the contrary, rhTPO could inhibit HL-60 cell proliferation and promote its apoptosis, and this effect was not related to c-MPL gene expression or protein expression. This evidence concerns the gene MPL and leukemia.