They suggested that fibronectin is produced and secreted by hepatocytes and exists in both tissue and plasma forms.[11] They proposed 2 hypotheses for fibronectin deposits: plasma fibronectin polymerizes to form β-pleated sheets with amyloid-like features under laboratory conditions[11,15] and similar amyloid-like aggregation of fibronectin is formed in tissues under a stressed cellular microenvironment.[11,16] Notably, after searching large-scale databases, fibronectin deposition was found to be extremely rare in both hepatocellular carcinoma and general surgical liver specimens.[16]. The gene discussed is FN1; the disease is hepatocellular carcinoma.