IGFBP1 and rheumatoid arthritis: KEGG enrichment analyses were conducted based on the top 100 co-expression genes to identify IGFBP1-related pathways and biological functions and significant pathways were shown in Figure 6A. The result showed that those genes were mainly enriched in complement and coagulation cascades, rheumatoid arthritis, collecting duct acid secretion, vibrio cholerae infection, epithelial cell signaling in Helicobacter pylori infection, and Wnt signaling pathway (Fig. 6A).