Combine with T2DM target proteins such as CCND1, CDK4, CDK1, CDK2, CDKN1A, RB1, CDK6, TP53, CCNB1 and CDKN1C, And further regulate that AGE-RAGE signal pathway, the PI3K-AKT signal pathway, the endocrine resistance pathway, the TNF signal pathway and the Toll-like receptor signal pathway as well as the insulin resistance pathway and the MAPK signal pathway of diabetic complications. This evidence concerns the gene RB1 and type 2 diabetes mellitus.