Using MCC algorithm of Cytoscape V3.9.0 software to screen the core targets of Jiaotai Pill in the treatment of T2DM, CCND1, CDK4, CDK1, CDK2, CDKN1A, CDK6, CCNB1, and CDKN1C in the top 10 targets are the regulators of cyclin-dependent kinases. This evidence concerns the gene CDK4 and type 2 diabetes mellitus.