Hence, the SALL1 multation might lead to the malformations of different tissues.[15] Si Dong et al[16] in 2003 verified the effect of losing of the spalt gene (the homolog of human SALL1 gene) in the drosophila melanogaster, which yielded morphologic defects in the testes, genitalia, and antennareported defects similar to those in humans with Townes-Brocks syndrome. This evidence concerns the gene SALL1 and Townes-Brocks syndrome.