In addition, the genetic mechanism of URSMS is not clear up to now, which might be related to genetic diseases as a autosomal recessive inheritance or an X-linked mode.[10,11] The genes of homeobox A13 and homeobox D13 related with sonic hedgehog pathway may be associated with URSMS.[12] Nakata et al[13] proposed candidate genes such as fibroblast growth factor 10, wingless-type mmtv integration site family, member 5a should be related with URSMS. Here, HOXD13 is linked to hereditary disease.