The result showed that ASITN/SIR grade and NLRP1 could be potential diagnostic biomarkers of poor prognosis of ischemic stroke patients (Fig. 3), the AUC of NLRP1 was 0.902, cutoff value 32.11 pg/mL, sensitivity 80.1%, specificity 78.9% and the AUC of ASITN/SIR grade was 0.871, cutoff value 2.5, sensitivity 83.8%, specificity 77.3%. Here, NLRP1 is linked to ischemic stroke.