Some alterations are more frequently observed in certain cancers, for example, FGFR3 mutations or translocations in bladder cancer, FGFR2 fusions or rearrangements in cholangiocarcinoma, and FGFR1 rearrangements in myeloid/lymphoid neoplasms.5, 6, 7, 8, 9. The gene discussed is FGFR3; the disease is cholangiocarcinoma.