We observed that FN1 overexpression promoted ITGA5‐mediated angiogenesis and downregulated FN1 in cervical cancer cells decreased angiogenesis by inhibited AKT signaling pathway in vitro, suggesting that fibronectin may play a critical role for ITGA5‐mediated angiogenesis in vitro by binding ITGA5 to regulate ECM features to activate AKT signaling pathway. Here, ITGA5 is linked to cervical cancer.