In this study, clinical data analysis established that high expression of ITGA5 is significantly correlated with poorer OS in patients with cervical cancer, IHC analysis established that high ITGA5 level was associated with cervical cancer progression, instead of a bystander, which reveal that more intensive postoperative treatment, such as chemoradiotherapy or individualized treatment, is necessary for patients with high ITGA5 expression. The gene discussed is ITGA5; the disease is cervical carcinoma.