Notably, MAPK4 expression was positively correlated with tumor infiltration by macrophages, Th1 cells, Th17 cells, follicular helper T cells (TFHs), neutrophils and eosinophils but negatively correlated with infiltration by CD8+ T cells, plasmacytoid DCs (pDCs) and T helper cells (Figure 9A,B). The gene discussed is CD8A; the disease is neoplasm.