Aberrant EGFR signaling, which is also enriched in glioma with high MAPK4 expression according to GSEA, also promotes the proliferation, angiogenesis, invasion and metastasis of cancer by downstream RAS–RAF–MEK–ERK, PI3K/AKT and PLC gamma‐PKC.22, 23, 24. The gene discussed is AKT1; the disease is central nervous system cancer.