Our data demonstrate that P‐AKT (T308) and P‐AKT (S473) levels are downregulated in glioma cells after MAPK4 knockdown, consistent with the positive correlation of P‐AKT (T308) and P‐AKT (S473) with MAPK4 expression in human glioma tissue. This evidence concerns the gene AKT1 and central nervous system cancer.