Genomic profiling in 499 Chinese PDAC patients revealed somatic driver mutations in KRAS, TP53, CDKN2A, SMAD4, ARID1A, RNF43, and pathogenic germline variants (PGVs) in cancer predisposition genes including BRCA2, PALB2, and ATM. The gene discussed is ARID1A; the disease is cancer.