Furthermore, hyperglycemia seen in type-1 and type-2 diabetes showed associated elevations in pro-fibrotic mediators including angiotensin II and TGF-β signaling in addition to reactive oxygen species (ROS) production; likewise, angiotensin-converting enzyme inhibitors reduce both collagen and TGF-β production in type-1 and type-2 diabetes [127-129]. Here, TGFB1 is linked to Hyperglycemia.