NLRP3 and Hepatic fibrosis: To assess the potential role of an NLRP3 inhibitor in age‐associated liver fibrosis, we employed a recently established aging mouse model of liver fibrosis caused by chronic‐plus‐binge alcohol feeding (Ramirez et al., 2017), which is distinct from a young mouse model that exhibits chronic‐plus‐binge alcohol feeding‐induced fatty liver and liver injury without detectable fibrosis.