SIRT1 and Hepatic fibrosis: Given the evidence that inhibition of SIRT1 is linked to excessive ECM deposition in old mice within the context of liver injury (Figure 1), we sought to determine the role of hepatocyte SIRT1 loss in liver fibrosis by using hepatocyte‐specific SIRT1 knockout (SIRT1 LKO, AlbCre+SIRT1f/f) mice (Li et al., 2014).