To test the possibility that dynamic matrix remodeling plays a role in pathological ECM degradation in SIRT1 LKO mice, we observed a twofold increase in the matrix remodeling enzyme—metalloproteinase 12 (MMP‐12)—in WT mice upon CCl4 injection, but the induction of MMP12 was further enhanced by threefold in the SIRT1 LKO mice (Figure 2e,f), suggesting that while a fibrogenic process can account for the severity of fibrosis observed in SIRT1 LKO mice, dysregulation of fibrolysis may also contribute to the progression of liver fibrosis. Here, MMP12 is linked to Hepatic fibrosis.