Furthemore, considering the concept of trans-synaptic propagation of pathology in AD (Tzioras et al. 2023), bi-directional spread of AD pathology through synaptic connections with other abnormal neurons may synergistically worsen the phenotypes of CA1 pyramidal neurons of Cyfip2 het mice compared to those of Cyfip2 cKO mice. This evidence concerns the gene CYFIP2 and Alzheimer disease.