APP and Alzheimer disease: Mechanistically, it has been proposed that reduced expression level of CYFIP2 induces aberrant local mRNA translation of several AD-related proteins (i.e. APP, BACE1, and CaMKIIα) at the synaptic compartment, thereby leading to the overproduction of Aβ and hyperphosphorylation of Tau in Cyfip2 het mice (Ghosh et al. 2020).