Mechanistically, it has been proposed that reduced expression level of CYFIP2 induces aberrant local mRNA translation of several AD-related proteins (i.e. APP, BACE1, and CaMKIIα) at the synaptic compartment, thereby leading to the overproduction of Aβ and hyperphosphorylation of Tau in Cyfip2 het mice (Ghosh et al. 2020). This evidence concerns the gene MAPT and Alzheimer disease.