CAMK2A and Alzheimer disease: To investigate whether cell-autonomous CYFIP2 reduction in excitatory pyramidal neurons is sufficient to induce AD-like phenotypes in the hippocampal CA1 region, we crossed floxed-Cyfip2 mice with CaMKIIα-Cre mice to generate Cyfip2 cKO (Cyfip2floxed/floxed; CaMKIIα-Cre) mice as previously described (Zhang et al. 2020).