PRMT5 and neoplasm: In addition to regulating the gene transcription by catalyzing the dimethylation of histone arginine residues (H2AR3, H3R8, and H4R3),11 PRMT5 also methylates the nonhistone arginine residues, such as tumor suppressor p53 and sterol regulatory element‐binding transcription factors sterol regulatory element‐binding protein (SREBP), to regulate the biological process of tumor cells.12, 13