HLA-C and cancer: Figure 6 demonstrates a substantial correlation between the expression of IKBIP and the number of invading immune cells (including B cells in 12 cancer types, CD4+ T cells in 13, CD8+ T cells in 23, macrophages in 23, neutrophils in 24, and DCs in 24 cancer types). The five types of immune pathways are chemokine, receptor, MHC, immuno-inhibitory, and immunostimulatory pathways. These findings demonstrated that IKBIP gene expression was positively correlated with immunomodulatory genes in the majority of malignancies (Supplementary Figure S3).