GTSE1 and nonpapillary renal cell carcinoma: To further investigate the role of GTSE1 in regulating the malignant progression of ccRCC, gain- and loss-of-function assays were conducted by inhibiting GTSE1 expression in OS-RC-2 cells or overexpressing GTSE1 expression in 786-O cells according to GTSE1 expression in ccRCC cells.