From the heatmaps, we could see a strong positive relationship between GTSE1 and PLK1, HJURP, TPX2, etc. Meanwhile, there was also an obvious negative relationship between GTSE1 and NR3C2, OSBPL1A, EMX2OS, etc. Remarkably, 46 of the top 50 positively regulated genes might serve as high-risk markers in ccRCC because of their high hazard ratio (HR, p-value < 0.05). This evidence concerns the gene PLK1 and nonpapillary renal cell carcinoma.