GTSE1 and nonpapillary renal cell carcinoma: From the results of CIBERSORT, we found that GTSE1 was also positively correlated with T regulatory cells (Tregs) and macrophages (monocytes, M0 macrophages, TAMs, M1 macrophages, and M2 macrophages), in which Tregs are known as the main manipulator creating an immunosuppressive TME by suppressing the function of Th1 cells, and the higher level of Treg infiltration was related to adverse clinical-pathological factors and poor prognosis in ccRCC (Kiniwa et al., 2007; Sakaguchi et al., 2020).