Considering the tight relationship between GTSE1 and microtubules and the causal association between microtubules and chemoresistance, the correlation between GTSE1 and HRD (homologous recombination deficiency) and the effect of GTSE1 on chemosensitivity to cisplatin in ccRCC were explored and demonstrated based on the TCGA-KIRC cohort and biological functional experiments. This evidence concerns the gene GTSE1 and nonpapillary renal cell carcinoma.