In this study, bioinformatic analysis based on TCGA and GEO databases and immunohistochemistry staining on ccRCC tissue chips demonstrated that GTSE1 was particularly upregulated in ccRCC tissues and that high GTSE1 expression was significantly correlated with adverse clinicopathological factors, including advanced stage, metastasis in lymph nodes and reduced survival time in OS, DSS, and FPI, which indicated that GTSE1 might serve as an oncogene in ccRCC. Here, GTSE1 is linked to nonpapillary renal cell carcinoma.