As shown in Table 1, five variants of VSX1 were detected in six unrelated KC families [1 intron heterozygous variant c.425-73C>T and 4 exon heterozygous variants, c.81C>T (p.R27R), c.479G>T (p.G160V), c.1025G>A (p.G342E), and c.49C>G (p.L17V)]. The gene discussed is VSX1; the disease is keratoconus.