POSTN and cancer: Numerous studies have shown the prognostic value of ARGs in cancer (Zheng et al., 2021; Cai et al., 2022; Tao et al., 2022), where Sun et al. found that POSTN may ultimately affect the prognosis of patients with LUAD by altering the immune microenvironment (Sun et al., 2022), and in our study, 55 ARGs associated with LUAD were obtained from 549 samples in the TCGA database.