SPAG5 and lung adenocarcinoma: It has been shown that LncRNA LINC00857 can regulate lung adenocarcinoma progression by targeting miR-1179/SPAG5 axis (Wang et al., 2020), LINC00460 -Hsa-Mir-338-FAM111/ZWINT pathway can be used as a prognostic biomarker for lung adenocarcinoma (Li et al., 2022), SYNPR-AS1 is significantly associated with overall survival of lung adenocarcinoma patients (Wu et al., 2020) and the prognostic potential of RBPMS-AS1 in lung adenocarcinoma (Wang L. et al., 2019), which is consistent with our findings.