IRF3 and Parkinson disease: Finally, in a neurotoxin (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, MPTP)-induced PD mouse model, AIM2 activation served to limit cGAS activity via interference with protein kinase B (AKT)-mediated IRF3 phosphorylation, and conditional knockout of AIM2 in microglia, but not peripheral cells, exacerbated PD-like disease severity (220).