Conversely CD8+ T cells from aged mice co-immunized with pADA displayed inhibited (purple bars) pro-inflammatory pathways including natural killer cell signaling, neuroinflammation signaling, SLE B cell signaling, TH1 signaling, and the coronavirus pathogenesis pathway which included CCL5 and CCR2 and numerous ribosomal subunit proteins (Figure 6C). Here, CD8A is linked to systemic lupus erythematosus.