Conversely, another study showed that the rs142933486 G>T polymorphism in PIK3CB improves PIK3CB mRNA and protein levels by derailing m6A-YTHDF2-dependent degradation mechanisms, which is significantly associated with the poor prognosis of PTEN-deficient pancreatic cancer patients (203). This evidence concerns the gene YTHDF2 and familial pancreatic carcinoma.