found that YTHDF1 restrains PPARγ expression in mice by promoting the translation of m6A-modified TRAF4 transcripts, while curcumin exerts an anti-obesity role by reducing the effect of ALKBH5 demethylation on TRAF4 m6A modification (105). This evidence concerns the gene ALKBH5 and obesity due to melanocortin 4 receptor deficiency.