SLC12A3 and Gitelman syndrome: In mammalian kidneys, NCC plays a significant role in the homeostasis of the Na+, Cl− and K+ ions; therefore, when changes in the activity of the cotransporter occurs, arterial blood pressure and K+ in plasma changes, resulting in diseases such as Gitelman syndrome (Gitelman et al., 1966; Cruz et al., 2001) and SeSAME syndrome (Bockenhauer et al., 2009; Cuevas et al., 2017), featuring low blood pressure and hypokalemia.