A gene cluster that was significantly downregulated in the Yap/Wwtr1 knockdown group contained genes primarily regulated by Tgfβ-1 and related to “hepatic fibrosis”, Stat3 pathway, and Th2 pathway— illustrating suppression of pro-fibrotic genes with depletion of Yap and Wwtr1. This evidence concerns the gene STAT3 and Hepatic fibrosis.