(36) examined the secondary effect of periodontitis-induced endothelial dysfunction and found that prebiotic β-glucan in addition to the reduction of periodontal parameters ABL and ABAL, also delayed coronary artery endothelial dysfunction by preventing oxidative stress, reducing circulating pro-inflammatory cytokines and inducible nitric oxide synthase suggesting a beneficiary impact on the coronary vascular bed (36). The gene discussed is NOS2; the disease is periodontitis.