Similar to other genes related to multisystem proteinopathy (e.g., VCP, hnRNPA2B1, and hnRNPA1) (15), pathogenic variants of SQSTM1 could lead to different diseases, such as ALS and PDB; the associated phenotypes may, thus, be affected by susceptibility alleles, rendering certain organ systems more likely to become involved. Here, SQSTM1 is linked to amyotrophic lateral sclerosis.