The MGE is the most studied region, with TFs such as Sox6, Mafb/cMaf, and Satb1 genetically downstream of Lhx6 that specify distinct aspects of CIN development (Zhao et al., 2008; Azim et al., 2009; Batista-Brito et al., 2009; Close et al., 2012; Denaxa et al., 2012; Vogt et al., 2014; Pai et al., 2019, 2020). Here, LHX6 is linked to cervical squamous intraepithelial neoplasia.