LHX6 and neurofibromatosis type 1: Moreover, a study revealed a role for MAPK hyperactivity on a cardinal MGE TF, Lhx6. Specifically, Loss of Nf1 in Nkx2.1-Cre lineages resulted in a depletion of Lhx6 transcript (Angara et al., 2020); this was also prominent in mutants that only lost one allele of Nf1, which is similar to humans diagnosed with Neurofibromatosis 1.