Astrocytes have recently been shown to play a crucial role in mediating positive reinforcement effects of OXT in the central amygdala of mice and rats (Wahis et al., 2021; Baudon et al., 2022) and a reduction in the number of OXTR-expressing astrocytes was found in specific brain regions in another transgenic mouse model of PWS, the Magel2tm1.1.Stw Mus mouse (Althammer et al., 2022). The gene discussed is OXTR; the disease is Prader-Willi syndrome.