CNTNAP2 and Anxiety: Although Cntnap2–/– animals have previously shown normal open field center time compared to controls, Poly I:C MIA is known to decrease center time in this paradigm, which is linked to increased anxiety (Meyer et al., 2005; Meyer, 2006; Brunner et al., 2015; Schaafsma et al., 2017; Kim et al., 2018).