TNF and myeloid sarcoma: Furthermore, B cells act as APCs for the activation of T cells, and T cells can secrete pro-inflammatory cytokines such as INF-γ, IL-6, and TNF-α associated with the transport of B cells into the CNS and have been linked to the activation of plasma cells in MS, closely related to the production, secretion, and infiltration of autoantibodies into the BBB (Kowarik et al., 2012).