TNF and myeloid sarcoma: Th17 cells, which are highly present in the CSF and brain lesions, are responsible for inducing the secretion of pro-inflammatory cytokines such as IL-17, INF-γ, IL-16, IL-21, IL-22, IL-23, and TNF-α, which are closely associated with the progression of MS owing to their pro-inflammatory features (Jadidi-Niaragh and Mirshafiey, 2011; Pot et al., 2011; Ruiz et al., 2019).